Form
Powder
MeltingPoint
>186°C
Doripenemisaβ-lactamantibioticinthecarbapenemclassandissparinglysolubleinaqueoussolution.Doripenemhasbeenfoundtobeeffectiveagainstextendedspectrumbeta-lactamase(ESBL)producing Enterobacteriaceae;amicroberesistanttomanyfirstlinebeta-lactamantibioticsandcertaincephalosporins.
364622-82-2
C15H24N4O6S2•H2O
438.52
β-lactamsinterferewithPBP(penicillinbindingprotein)activityinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresiduesprovidingadditionalstrengthtothecellwall.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedandultimatelyleadstocelllysisanddeath.Resistancetoβ-lactamsiscommonlyduetocellscontainingplasmidencodedβ-lactamases;however,carbapenems,includingdoripenem,arehighlyresistanttoβ-lactamases.
2-8°C
2941.90.5000
DoripenemisabroadspectrumantibiotictargetingawiderangeofgrampositiveandgramnegativebacteriaincludingPseudomonasaeruginosa.
Powder
>186°C
TOKU-E公司1981年成立于日本东京,由来自全球的顶尖专业人士组成,拥有世界领先的体外抗生素生产技术,并快速成长为世界领先的超纯抗生素供应者,以低廉的价格提供最全面的超纯抗生素,其纯度大于99%,用于动物细胞培养、植物组织培养、微生物、抗真菌及诊断等科研领域,允许研究者提高抗生素浓度,并消除污染,降低对细胞的伤害,从而提高筛选效率;该公司还提供精细化学试剂,如超纯丙烯酰胺、无尘SDS、胍盐等,极大提高了实验的精确性和安全性,可满足生命科学研究领域各科研机构,标准化组织机构的高标准需求。