BacitracinisabranchedcyclicdodecylpeptideantibioticproducedbyBacilluslicheniformisandsomestrainsofBacillussubtilis(Azevedoetal1993).Itissynthesizedasamixtureofupto50closelyrelatedcongeners/fractions.Bacitracinincludesthefollowingfractions:A,B1,B,B2,B3,C,C1,C2,C3,D,E,F,G,H1,H2,H3,I1,I2,I3,andX.Bacitracinisfreelysolubleinaqueoussolution.

ForallBacitracinproducts,clickhere.

CASNumber

1405-87-4

MolecularFormula

C₆₆H₁₀₃N₁₇O₁₆S

MolecularWeight

1422.69

MechanismofAction

Bacitracinpreventsphosphorylationofbactoprenol,atransportproteinwhichcarriespeptidoglycancomponentsoutsidethecellmembrane.Withouttheactivephosphorylatedbactoprenol,peptidoglycansynthesiscannotbecompletedandthecelllyses.ResistancetoBacitracinisunderstoodtoinvolvetwomechanisms:Aproteintransporter(BcrABC)whichpumpsbacitracinoutofthecellafterithasentered,andviaanotherprotein(BacA)whichprovidestheactivephosphorylatedbactoprenolfromadifferentsyntheticpathway.

StorageConditions

2-8°C

TariffCode

2941.90.5000

Spectrum

BacitracininhibitscellwallsynthesisinGram-positivebacteriaincludingStreptococcuspyogenesandStaphylococcusaureus.RepresentativeMICvaluesinclude:

• Staphylococcusaureus2µg/mL->32µg/mL
• Streptococcusagalactiae>16µg/mL(GroupB)
• ForacompletelistofbacitracinMICvalues,clickhere.

TOKU-E公司1981年成立于日本东京，由来自全球的顶尖专业人士组成，拥有世界领先的体外抗生素生产技术，并快速成长为世界领先的超纯抗生素供应者，以低廉的价格提供最全面的超纯抗生素，其纯度大于99%，用于动物细胞培养、植物组织培养、微生物、抗真菌及诊断等科研领域，允许研究者提高抗生素浓度，并消除污染，降低对细胞的伤害，从而提高筛选效率；该公司还提供精细化学试剂，如超纯丙烯酰胺、无尘SDS、胍盐等，极大提高了实验的精确性和安全性，可满足生命科学研究领域各科研机构，标准化组织机构的高标准需求。