CyclosporinDisahydroxylatedmetaboliteofcyclosporinA(CsA).CyclosporinDandothercyclosporinmetaboliteshavebeenfoundtohavelower(<10%)immunosuppressantactivitythancyclosporinA(CsA). CyclosporinDhasbeenfoundtoreversedaunorubicinresistanceinsomeresistantleukemiacellsbypossIBLyinhibitingtheeffluxfunctionsofP-glycoprotein.

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CASNumber

63775-96-2

MolecularFormula

C₆₃H₁₁₃N₁₁O₁₂

MolecularWeight

1216.63g/mol

MechanismofAction

CyclosporinD(andothercyclosporinA(CsA)metabolites)havelowerimmunosuppressantactivitybutmostlikelyoperateunderthesamemechanismascyclosporinA(CsA)describedbelow.

CyclosporinA(CsA)immunosuppressantactivitystemsfromitsABIlitytopreventT-cellactivationbyblockingspecificcytokinetranscriptiongenes.AfterenteringaT-cell,cyclosporinA(CsA)associateswithubiquitouscytosolicproteinscalledcyclophilinswhichaidinproteinfolding.CyclosporinA(CsA):cyclophilincomplexestogetherbindcalcineurin,(anothercytosolicprotein)effectivelyblockingthepathwaytoIL-2genetranscriptionandT-cellactivation.

StorageConditions

-20°C

TariffCode

2933.79.8500

Specifications:

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